For laboratory research use only. Not for human or veterinary use.
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TB-500 5 mg ≥99% (HPLC) RESEARCH USE ONLY Not for human or veterinary use

TB-500

Thymosin β4 actin-binding fragment used in wound-healing and cardiac-repair research.

Size
  • Lot-specific certificate of analysis included
  • Ships lyophilized in a sealed glass vial
  • Orders over $200.00 ship free in the US

For laboratory research use only. Not for human or veterinary use. Sold only to purchasers 21 or older who accept the research use policy.

Research overview

TB-500 is a synthetic version of the actin-binding region of thymosin beta-4 (Tβ4), a 43-amino-acid protein present in nearly all mammalian cells. The fragment supplied here is the N-acetylated heptapeptide LKKTETQ, corresponding to residues 17–23 of Tβ4.

Thymosin β4 sequesters monomeric G-actin and has been studied extensively in dermal wound healing, corneal epithelial repair and post-infarction cardiac models. The short fragment is the portion most often cited for actin-related activity in cell-based assays.

Areas of published research

  • Actin polymerization and cell migration assays
  • Dermal and corneal wound-healing models
  • Cardiac tissue repair following ischemic injury
  • Inflammatory signaling in injured tissue

The list above summarises where this compound appears in the scientific literature. It describes research activity, not properties or effects of any product sold here.

Storage and handling

  • Lyophilized vials: store at −20 °C for long-term storage, or 2–8 °C for up to several weeks. Keep sealed and protected from light.
  • Allow the vial to reach room temperature before opening, so moisture does not condense on the cold powder.
  • After reconstitution with bacteriostatic water, store at 2–8 °C and use within 28 days. Avoid repeated freeze–thaw cycles.
  • Add diluent slowly down the inside wall of the vial and swirl gently; do not shake.

Calculate a reconstitution for this vial

Documentation

Each lot is tested by an independent laboratory for purity (RP-HPLC) and identity (mass spectrometry). The certificate of analysis for your lot ships with the order; copies for any lot can be requested through the contact page with the lot number from the vial label. Read our guide on how to read a certificate of analysis.

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